Current 2017 status of antibiotic resistant micro-organisms in the United States and globally. Medical and societal issues promoting resistant micro-organisms. Mechanisms and biological pressures promoting emergence of resistant bacterial strains. Clinical indications of viral sinusitis as compared with bacterial sinusitis. Predominant bacterial strains and clinical efficacy of different antibiotics in the control of sinusitis. General prevalence of resistant bacterial strains. Strategies to prevent overuse and inappropriate prescribing of antibiotics. Current recommendations for treatment of sinusitis.