Non-surgical antimicrobial periodontal therapies. Reviews the prevailing theory of periodontal disease pathogenesis. Rationale for non-surgical periodontal therapies. Current theoretical and practical approaches to periodontal therapy. Reviews the four latest FDA-approved pharmaceutical agents available as adjunctive and stand-alone treatments for adult periodontitis: Arestin, Atridox, PerioChip and Periostat. Clinical aspects of administering these agents.